Allegra aside, Woosley’s work
In 1992, doctors discovered Seldane was dangerous for people with liver Fexofenadine (Allegra) is an antihistamine used to relieve allergy symptoms and hives
-based manufacturer of the antihistamine Seldane faced the threat of the Food & Drug Administration pulling its drug and instead came way as a winner by using the crisis to tout its new drug Allegra
However, some patients were taking medications that blocked the action of P450, so these patients could not convert seldane to allegra
However, some patients were taking medications that blocked the action of P450, so these patients could not convert seldane to allegra
Terfenadine, the active ingredient in Seldane, has become one of the classic examples of why drug metabolism is very critical in the development process
It alleviates symptoms such as runny nose, itchy, watery eyes and sneezing
Fexofenadine is without the risks of terfenadine and, as a metabolite of terfenadine, is a well-known
Also, Seldane just went generic
Never take DXM with, or up to two weeks before or six weeks after, the prescription "non-drowsy The Food and Drug Administration (FDA) has announced its intention to withdraw the approval of terfenadine (Seldane), terfenadine with pseudoephedrine (Seldane D), and generic versions of terfenadine
5 times more likely than Allegra to cause sedation; however, Zyrtec is still much less sedating than older antihistamines such as promethazine
This risk is higher when terfenadine clearance is blocked by drugs like macrolide antibiotics or antifungal therapy