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Starting with 30 mg four times daily, before meals and at bedtime, dosage should be increased gradually (given in divided doses three or four times daily) at 1- to 2
There have been reports of diltiazem
antiarrhythmics
IV over 2 minutes
Routes of Administration: IV, PO
0
240mg
13 mg/kg and was not associated
25 mg/kg actual body weight as a bolus administered over 2 minutes (20 mg is a reasonable dose
Switching to CARDIZEM LA Tablets Patients controlled on diltiazem alone or in combination with other medications may be switched to CARDIZEM LA once a day at the nearest equivalent
13 mg/kg was associated with significantly improved times to achieve HR control compared to < 0
Patients with low body weights should be dosed on a mg/kg basis
To avoid hypotension, we have empirically used a lower dose of diltiazem
25mg/kg (average adult dose 20mg) over 2 min; If, after 15min 1st dose is tolerated but inadequate re-bolus 0
Diltiazem Hydrochloride Injection is for direct intravenous bolus injection and continuous intravenous infusion
Subsequent intravenous bolus doses should be individualized for each patient
The second bolus dose of diltiazem hydrochloride should be 0
However, no studies exist comparing oral (PO) immediate release and IV continuous infusion Adult patients were categorized by the dose of diltiazem received; 10 mg standard dose or 0
By slowing electrical conduction in the heart, diltiazem has been used in treating abnormally fast heart rhythms, such as atrial fibrillation
2 nd dose: Give 0
5 mg: 5 to 30 minutes for IV therapy or 30 minutes to 2 hours for Children—Use and dose must be determined by your doctor
Steps to Convert from IV to Oral Diltiazem: Step 1 = Calculate the equivalent oral daily dose of diltiazem based on the IV infusion rate (see above) Step 2 = Divide the equivalent total daily dose by 4 to determine the dose to be given every 6 hours of the IR oral dosage form
5 mg/hr to 260 mg/day · 10 mg/hr to 330 mg/day · 15 mg/hr to 480 mg/day
The average optimum dosage range is 180 to 360 mg/day
25 mg/kg, ranging diltiazem dosing (1) Initial loading dose: Start with 0
Consider a reduction in the infusion rate after the target heart rate is reached
Calculate total daily oral dose 2